Rich enzyme libraries by independent research and development
Over 2000 enzyme varieties, with extremely high catalytic efficiency compared to non-biological catalysts, more than 100 times that of conventional catalysts.
BONTAC has independently developed a directed evolution platform, creating enzymes that do not exist in nature from scratch. With a current enzyme library of over 2000 varieties, the company utilizes directed evolution for genetic mutation and recombination. Through high-throughput AI screening, they repeatedly select superior enzyme varieties, forming a rich proprietary enzyme library. Compared to non-biological catalysts, these enzymes have extremely high catalytic efficiency, which is 100 to 1000 times more than that of conventional catalysts.
The classical retrosynthetic analysis in chemical synthesis is introduced into biosynthesis.
The target enzyme is subjected to the directed evolution with irrational，semi-rational or rational design, followed by the screening of high-through put mutation library to construct the standard target enzyme library.
The selection of expression vectors and the construction of target strains are completed by the combined screening of components such as vector resistance，promoter，tag and expression host.
The enzyme expression process is optimized by medium formulation, inducer and process control.
Catalytic process parameters are optimized for better catalytic efficiency, higher yield and better product quality.
Over 2000 enzyme varieties, with extremely high catalytic efficiency compared to non-biological catalysts, more than 100 times that of conventional catalysts.
Developing an optimized process system for the preparation of coenzyme crude products through a one-step multi-enzyme cooperative catalysis reaction (i.e., multi-enzyme one-pot reaction).
Purification technology with low cost and high yield. The process of medium pressure column purification was abandoned, and the problem of hard decolorization of NAD and NMN products caused by enzyme catalysis was solved.
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Coenzyme annual production capacity
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Enzyme catalysis cutting-edge R&D personnel
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Research collaboration platform
Dr. Cheung, the chief scientist and founder of BONTAC, was once engaged in research work at the Institute of Genetics and Developmental Biology in Chinese Academy of Sciences, Cornell University and City University of Hong Kong. She has been dedicated to the application of biological enzyme catalysis technology into the green bio-manufacturing industrialization of coenzymes, medical intermediates and natural products for over 20 years. Notably, Dr. Cheung has applied approximately 90 invention patents at home and abroad, authorized over 60 patents and conducted key R&D plan projects in Guangdong province as well as key science and technology projects in Shenzhen city.
In the past two years, under her leadership, BONTAC has obtained series of honors such as KPMG China's top 50 Biotech Innovation Enterprises in 2023，2023 Deloitte China Life Sciences & Healthcare Rising Star and the enterprise with the most growth potential in future great health. In addition, NMN, phosphatidylserine, NADH, ginsenoside Rh2 and stevioside RD in BONTAC are listed as famous high-tech products in Guangdong province. In the development of group standards for multiple products such as NMN and NADH, Dr. Cheung plays a leading role as well.
Nearly 100 people research and development team.
Among them, doctors and masters account for more than 90%.
Breaking through the 4th generation technological barriers, we have become the world's first high-tech enterprise to achieve industrial ton level production of coenzyme using full enzyme catalysis technology. With professional laboratories, strict quality standards, and a mature and complete quality assurance system, we can comprehensively control product quality. Whether in terms of scale or equipment, BONTAC ensures the reliability and stability of product quality at the highest level.
The Bangtai Biological Coenzyme Production Base covers an area of 16000 square meters and is located in Zhongshan. Since its mass production in 2014, it has always adhered to the technology of whole enzyme catalysis and continuously iterated. The fourth generation of whole enzyme catalysis technology has been fully put into production and online, with an annual production of 100 tons of coenzyme. The Fuyang Natural Products Super Factory is under construction.
Harvard University
Cornell University
SIAT
TIBCAS
QIBEBT
State Key Lab of Space Medicine Fundamentals And Appliaction
Shenzhen Bay Laboratory
CUHK
THU
PKU
FUDAN
SZU
CPU
Naval Medical University
University of Helsinki
ZJU
WHU
SYSU
SCUT
ECUST
ECNU